Lab category: Bio-macromolecules in solution

MASTERlab is an integrated, experimental laboratory composed of OMNISEC (a size exclusion chromatography multidetector, SEC-MD), nano-DSC (differential scanning calorimetry) and Affinity ITC (Isothermal titration calorimetry) fundamental for reliable and in-depth characterization of natural and (semi)synthetic (bio)macromolecule-based systems in solution. In particular, OMNISEC, thanks to the combination of light scattering, viscosimeter, refractive index (RI) and UV detectors will allow to measure absolute molecular weight, molecular size and intrinsic viscosity, and generate information on macromolecular structure, conformation, aggregation and branching. Both Affinity ITC and nano-DSC are calorimeters specifically used to determine the energies driving the affinity/binding/aggregation interactions between a (bio)macromolecule and small (pigments, dyes, drugs, pollutants, metals) or large (polymers, proteins, RNA, DNA) molecules and the thermal stability of macromolecules. The MASTERlab activities and facilities are adaptable for both academic and industrial researchers dealing with (bio)macromolecule-related systems in the fields of chemistry, (nano)materials, biology, pharmaceutics and life science at large.